Premium
Cardiac Conduction Abnormalities and Atrial Arrhythmias Associated with Salicylate Toxicity
Author(s) -
Mukerji Vaskar,
Alpert Martin A.,
Flaker Greg C.,
Beach C. L.,
Weber Robert D.
Publication year - 1986
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1986.tb03449.x
Subject(s) - aspirin , medicine , toxicity , cardiology , sinus rhythm , salicylic acid , pulmonary edema , anesthesia , atrial fibrillation , pharmacology , chemistry , lung , biochemistry
Cardiac side effects from aspirin are uncommon; however, severe acid‐base imbalance, pulmonary edema, ventricular ectopic activity and cardiopulmonary arrest have been reported in patients with toxic serum salicylate concentrations. We saw a patient with salicylate toxicity who developed a variety of sinus and atrioventricular nodal conduction disturbances and atrial arrhythmias with a relatively low toxic serum salicylate concentration. The cardiac rhythm returned to normal as the serum salicylate concentration decreased, and results of subsequent electrophysiologic testing and Holter monitoring were normal. A low serum albumin level may have resulted in altered salicylate binding in this patient, thereby increasing the availability of unbound (active) drug for toxic effects.