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Pharmacology and Clinical Efficacy of Terfenadine, a New H 1 ‐receptor Antagonist
Author(s) -
Connell John T.
Publication year - 1985
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1985.tb03418.x
Subject(s) - terfenadine , pharmacology , antagonist , anticholinergic , histamine h1 receptor , placebo , sedation , chlorpheniramine maleate , medicine , drug , anesthesia , chemistry , receptor , alternative medicine , pathology , chromatography
Terfenadine is the first of a new class of non‐sedating H 1 antihistamines. It differs from chlorpheniramine in its lower anticholinergic activity in rabbit salivation tests. In animal model distribution studies, the drug is not found in the brain. In most clinical studies sedation attributed to terfenadine was on the order of that observed with placebo. Clinical trials of efficacy show that at best terfenadine is slightly less effective than or as effective as chlorpheniramine.