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Analgesic Effect of Graded Doses of Flurbiprofen in Post‐Episiotomy Pain
Author(s) -
Sunshine Abraham,
Olson Nancy Z.,
Laska Eugene M.,
Zighelboim Itic,
Castro Ana,
Sarrazin Cherokee
Publication year - 1983
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1983.tb03246.x
Subject(s) - flurbiprofen , analgesic , episiotomy , medicine , placebo , aspirin , anesthesia , adverse effect , pain relief , pregnancy , alternative medicine , pathology , biology , genetics
Our purpose was to evaluate the analgesic efficacy and safety of single oral doses of flurbiprofen 25, 50 and 100 mg, aspirin 600 mg, and placebo in the relief of moderate to severe post‐episiotomy pain. One hundred and fifty‐two evaluable patients completed a randomized, double‐blind, stratified, parallel groups study. They were observed over a six hour period by one nurse‐observer. Based upon each of the summary efficacy measures SPID, TOTAL and PEAK % and most of the hourly direct measures of pain intensity and pain relief, each of the four active treatments were statistically superior to placebo. Flurbiprofen 25 mg appeared to be slightly less effective than aspirin 600 mg, but the differences were not statistically significant. Flurbiprofen 50 and 100 mg were quite similar and were significantly more effective than aspirin 600 mg and flurbiprofen 25 mg. There were no observed or reported adverse effects.