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The Effect of 3‐Month Ingestion of Ginkgo biloba Extract on Pancreatic β‐Cell Function in Response to Glucose Loading in Normal Glucose Tolerant Individuals
Author(s) -
Kudolo George B.
Publication year - 2000
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.2000.tb05991.x
Subject(s) - ginkgo biloba , ingestion , insulin , medicine , endocrinology , ginkgoales , blood pressure , diabetes mellitus , glucose tolerance test , pharmacology , insulin resistance , chemistry , pharmacognosy , biochemistry , biological activity , in vitro
Ginkgo biloba extract is ingested on a chronic basis for enhancing mental focus and improving cognitive function in the elderly. This study was undertaken to determine the effect of Ginkgo biloba extract on glucose‐stimulated pancreatic β‐cell function in normal glucose‐tolerant individuals. Twenty individuals (14 females and 6 males, ages 21–57 years) underwent a 2‐hour 75 g oral glucose tolerance test (OGTT) before and after ingestion of Ginkgo biloba extract (120 mg/day at bedtime) for 3 months . Ginkgo biloba extract ingestion caused a decrease in systolic blood pressure from 125 ± 15 to 118 ± 12 mmHg ( p < 0.05) and in diastolic blood pressure from 86 ± 10 to 68 ± 10 ( p < 0.01). Fasting plasma insulin and C‐peptide were increased, and the insulin and C‐peptide areas under the curve during the OGTT changed from 136 ±55 to 162 ± 94 μU/ml/h ( p = 0.1232) and 9.67 ± 5.34 to 16.88 ± 5.20 ng/ml/h ( p < 0.001), respectively. The observed dissimilar insulin/C‐peptide response curves may be due to Ginkgo biloba‐ induced increase of the rate of insulin metabolic clearance .