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Mycophenolic Acid Area under the Curve Values in African American and Caucasian Renal Transplant Patients Are Comparable
Author(s) -
Shaw Leslie M.,
Korecka Magdalena,
Aradhye Shreeram,
Grossman Robert,
Bayer Linda,
Innes Christine,
Cucciara Andrew,
Barker Clyde,
Naji Ali,
Nicholls Andrew,
Brayman Kenneth
Publication year - 2000
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.2000.tb05988.x
Subject(s) - mycophenolic acid , pharmacokinetics , mycophenolate , medicine , renal function , clearance , transplantation , urology , area under the curve , pharmacology , prodrug , metabolite , kidney transplantation
The possibility of an effect of ethnicity on the pharmacokinetics of mycophenolic acid, the immunosuppressive metabolite of the prodrug mycophenolate mofetil, was studied over 90 days following renal transplantation in African American (n = 13) and Caucasian patients (n = 20). Since renal dysfunction and time after transplant surgery are two factors known to alter mycophenolic acid pharmacokinetics, two‐way analysis of variance of the data at each time point with ethnicity and renal function status as covariates was used to evaluate the possibility of an ethnicity effect on the pharmacokinetic parameters. No statistically significant difference based on ethnicity was detected for the primary pharmacokinetic parameters, abbreviated mycophenolic acid area under the concentration‐time curve (MPA AUC), or the predose trough concentration on study days 4,7,14,28, or 90. A statistically significant decrease in MPA AUC and increase in oral apparent clearance were observed in renally impaired patients regardless of ethnicity on days 4, and 4 and 7, respectively. The suggested mechanism for these differences is uremia‐induced increased MPA free fraction, leading to a temporary increased clearance for this restrictively cleared drug.