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Absence of a Pharmacokinetic Interaction Between Intravenous Theophylline and Orally Administered Levofloxacin
Author(s) -
Gisclon Lee G.,
Curtin Christopher R.,
Fowler Cynthia L.,
Williams R. Rex,
Hafkin Barry,
Natarajan Jaya
Publication year - 1997
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1997.tb04362.x
Subject(s) - theophylline , pharmacokinetics , levofloxacin , crossover study , cmax , placebo , bronchodilator , medicine , pharmacology , volume of distribution , steady state (chemistry) , anesthesia , oral administration , chemistry , antibiotics , asthma , biochemistry , alternative medicine , pathology
A randomized, placebo‐controlled, two‐way crossover study in 16 healthy men was performed to determine the effect of orally administered levofloxacin at steady‐state conditions, given at 500 mg every 12 hours, on the pharmacokinetics of theophylline given as a single 4.5‐mg/kg intravenous infusion. Participants were assigned randomly to receive theophylline with levofloxacin in one study period and theophylline with placebo in the other period. Fourteen individuals completed the study. Mean (± SD) values for theophylline pharmacokinetic parameters for the levofloxacin and placebo treatments, respectively, were peak plasma concentrations (C max ) of 11.4 (1.8) μg/mL and 10.7 (1.3) μg/mL; areas under the concentration time curve from time 0 extrapolated to infinity (AUC 0‐∞ ) of 124 (32) μg · hr/mL and 126 (30) μg · hr/mL; volumes of distribution at steady state (Vd ss ) 31.7 (3.5) L and 32.0 (3.9) L; clearances (Cl) of 48.6 (11.6) mL/min and 47.4 (10.3) mL/min; and half‐lives (t 1/2 ) of 8.1 (1.9) hours and 8.2 (1.8) hours. There were no statistically significant differences between treatments for any of these parameters. There was no pharmacokinetic interaction between levofloxacin administered orally at steady‐state conditions and intravenously administered theophylline.