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Effect of Diltiazem on Intraarterial Blood Pressure and Heart Rate During Stress Testing in Patients with Angina: A Gender Comparison Study
Author(s) -
Klassen Gerald A.,
Yeung Pollen K. F.,
Barclay Katherine D.,
Pollak P. Timothy,
Hung Orlando R.,
Buckley Susan J.
Publication year - 1997
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1997.tb04306.x
Subject(s) - diltiazem , medicine , blood pressure , angina , heart rate , cardiology , bruce protocol , pulse pressure , anesthesia , myocardial infarction , calcium
The purpose of this study was to measure the blood pressure and electrocardiographic responses of a small, matched group of women (n = 8) and men (n = 9) who experienced typical, effort angina during an exercise on the treadmill (up to the second stage of a Bruce protocol). These responses were measured before and after therapy with diltiazem (60 mg four times daily for 1 week). Reports of previous studies have described significant gender differences in blood pressure responses to diltiazem in healthy volunteers tested with the same protocol. In contrast to the data in healthy individuals, gender differences in blood pressure responses to exercise before and after diltiazem administration were not observed. Results of analysis of pulse pressure responses to exercise were also similar in male and female patients with angina. A significant postexercise drop in blood pressure was observed, which was augmented by diltiazem. These data suggest that gender differences in drug action may be difficult to demonstrate in patients with vascular disease.