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Effects of Theophylline on Respiratory Drive in Patients with Chronic Obstructive Pulmonary Disease
Author(s) -
Ashutosh Kumar,
Sedat Mohammad,
FragaleJackson Jody
Publication year - 1997
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1997.tb04293.x
Subject(s) - theophylline , medicine , bronchodilator , anesthesia , respiratory minute volume , respiratory system , copd , vital capacity , placebo , asthma , lung , pathology , lung function , alternative medicine , diffusing capacity
Effects of theophylline administration on the respiratory drive were studied in seven patients with chronic obstructive pulmonary disease (COPD). End tidal CO 2 (PetCO 2 ), minute ventilation (Ve), forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC), oxygen consumption (VO 2 ), carbon dioxide output (VCO 2 ), serum theophylline level (STL), ventilatory response (VeR), and mouth occlusion pressure response (OPR) to rise in PetCO 2 on rebreathing were measured before and at 2‐hour intervals after oral administration of 5 mg/kg anhydrous theophylline or placebo. Mouth occlusion pressure response and VeR showed a significant increase after theophylline but not after placebo. Significant positive correlation between changes (Δ) in STL and OPR (ΔOPR = 0.025 + 0.8 ΔSTL; SEE = 1; r = 0.4; P < 0.005) and between STL and VeR (VeR = 0.82 + 0.055 STL ± SEE = 0.7; r = 0.46; P < 0.01) and an inverse correlation between ΔSTL and ΔPetCO 2 (ΔPetCO 2 = 13.8 − 0.59 ΔSTL; SEE = 9.1; r = 0.61; P < 0.001) were noted. There was no correlation between the indices of respiratory drive and FEV 1 , Ve, VO 2 , or VCO 2 . It is concluded that theophylline increases respiratory drive in clinically employed doses independently of its bronchodilator or metabolic effects.