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Acebutolol Overdose Treated with Hemodialysis and Extracorporeal Membrane Oxygenation
Author(s) -
Rooney M.,
Massey K. L.,
Jamali F.,
Rosin M.,
Thomson D.,
Johnson D. H.
Publication year - 1996
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1996.tb04247.x
Subject(s) - acebutolol , hemodialysis , medicine , clearance , extracorporeal membrane oxygenation , extracorporeal , anesthesia , surgery , urology , propranolol
A case involving a 27‐year‐old woman who ingested an overdose of acebutolol is presented. Extracorporeal membrane oxygenation was initiated to stabilize the patient's condition before commencing hemodialysis. S‐diacetolol (the N‐acetelation product of acebutolol) was cleared with hemodialysis. It is suggested that extracorporeal membrane oxygenation may be of short‐term benefit in the treatment of overdoses with β‐adrenergic agents such as acebutolol when accelerated clearance with hemodialysis is anticipated.