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Lack of Effect of Orlistat on the Bioavailability of a Single Dose of Nifedipine Extended‐Release Tablets (Procardia XL) in Healthy Volunteers
Author(s) -
Melia Angela T.,
Mulligan Thomas E.,
Zhi Jianguo
Publication year - 1996
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1996.tb04211.x
Subject(s) - orlistat , bioavailability , nifedipine , crossover study , medicine , pharmacology , placebo , pharmacokinetics , bioequivalence , area under the curve , absorption (acoustics) , weight loss , calcium , obesity , pathology , physics , acoustics , alternative medicine
Orlistat, a lipase inhibitor, reduces dietary fat absorption, and thus could potentially alter the absorption of some concomitantly administered drugs, such as the nifedipine gastrointestinal therapeutic system (GITS). To assess the effect of orlistat on the bioavailability of nifedipine GITS, a third party‐blind, placebo‐controlled, randomized, two‐way crossover study was performed in 18 healthy volunteers. Each participant received single 60‐mg oral doses of nifedipine GITS (Procardia XL; Pfizer Labs, New York, NY) on the fourth day of treatment with 120 mg of orlistat or placebo three times a day for 6 days. The two treatments were separated by a washout period of at least 1 week. Serial blood samples were collected before and at appropriate intervals after each nifedipine dose to determine plasma concentrations of nifedipine. The 90% confidence intervals for the ratio of geometric least‐square means for maximum concentration (C max ) and area under the concentration‐time curve (AUC o‐t ) and for the difference of arithmetic least‐square means for time to maximum concentration (t max ) indicate that the bioavailability of nifedipine was not altered by treatment with orlistat. Therapeutic doses of 120 mg of orlistat three times daily do not significantly alter the bioavailability of a single 60‐mg oral dose of nifedipine GITS in healthy volunteers.