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No Evidence of a Direct Venodilatory Effect of Furosemide in Healthy Human Subjects
Author(s) -
Harada Kazuhiro,
Ohmori Masami,
Fujimura Akio,
Ohashi Kyoichi
Publication year - 1996
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1996.tb04198.x
Subject(s) - furosemide , amrinone , inotrope , diuretic , vasodilation , medicine , phenylephrine , anesthesia , cardiology , blood pressure
The present study was undertaken to examine whether furosemide, a loop diuretic, has a direct venodilatory effect in healthy male subjects. Furosemide, or amrinone, an inotropic agent with a vasodilatory action, was infused into a dorsal hand vein that had been preconstricted by phenylephrine. The diameter of the vein was measured by a linear variable differential transformer. Venodilation was observed during the infusion of amrinone, but such a response was not detected with furosemide. These findings do not support the hypothesis that furosemide has a direct venodilatory effect in healthy human subjects.