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Interaction of Meloxicam with Cimetidine, Maalox, or Aspirin
Author(s) -
Busch Ulrich,
Heinzel Gunther,
Narjes Hans,
Nehmiz Gerhard
Publication year - 1996
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1996.tb04155.x
Subject(s) - meloxicam , cimetidine , pharmacokinetics , pharmacology , bioavailability , aspirin , potency , medicine , piroxicam , concomitant , plasma concentration , drug interaction , area under the curve , chemistry , biochemistry , in vitro , alternative medicine , pathology
Meloxicam is a new enol carboxamide nonsteroidal antiinflammatory drug (NSAID). Preclinical studies have indicated that it possesses a high antiinflammatory potency and a low ulcerogenic potency. This open, randomized, crossover study was conducted to examine the effects of aspirin, the antacid Maalox (Rhone‐Poulenc Rorer, Cologne, Germany), and cimetidine on the pharmacokinetics and bioavailability of a single oral dose of meloxicam 30 mg in healthy male volunteers. Plasma concentrations of meloxicam were determined and subjected to noncompartmental pharmacokinetic analysis. Meloxicam was well tolerated, and concomitant treatment with cimetidine or Maalox had little or no effect on the plasma concentration—time curves, maximum plasma concentration (C max ), or the area under the plasma concentration—time curve (AUC 0‐∞ ) of meloxicam. Concurrent treatment with aspirin increased plasma concentrations of meloxicam, increasing C max by approximately 25% and AUC 0‐∞ by 10%. These differences were not considered to be clinically relevant, and no adjustments of meloxicam dose should be required with coadministration of aspirin, Maalox, or cimetidine.