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Gastrointestinal Absorption of Pravastatin in Healthy Subjects
Author(s) -
Triscari Joseph,
O'Donnell Denis,
Zinny Miguel,
Pan Henry Y.
Publication year - 1995
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1995.tb05002.x
Subject(s) - pravastatin , bioavailability , metabolite , duodenum , pharmacokinetics , ileum , stomach , pharmacology , jejunum , chemistry , absorption (acoustics) , active metabolite , medicine , biochemistry , cholesterol , materials science , composite material
The bioavailability of pravastatin, a hypocholesterolmic agent, may be enhanced by decreasing its exposure to stomach contents, where it may be converted nonenzymatically to a relatively inactive metabolite. The pharmacokinetics of pravastatin and its metabolite were determined after infusion of pravastatin directly into the stomach (locus for greatest bioavailability for the metabolite), duodenum (greastest bioavailability for pravastatin), jejunum, or ileum. An enterically coated formulation of pravastatin may increase its bioavailability.