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Lisinopril Versus Placebo in the Treatment of Heart Failure: The Lisinopril Heart Failure Study Group
Author(s) -
Beller Barry,
Bulle Thomas,
Bourge Robert C.,
Colfer Harry,
Fowles Robert E.,
Giles Thomas D.,
Grover John,
Whipple James P.,
Fisher Mary B.,
Jessup Mariell,
Naggar Charles,
Alexander Sidney,
Parker Brent M.,
Smith Ellen,
Weidler Donald J.,
Wertheimer John
Publication year - 1995
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1995.tb04107.x
Subject(s) - lisinopril , digoxin , heart failure , medicine , placebo , ejection fraction , cardiology , ace inhibitor , angiotensin converting enzyme , anesthesia , blood pressure , alternative medicine , pathology
Lisinopril, a long‐acting, angiotensin‐converting enzyme inhibitor, was compared with placebo in a randomized, parallel, double‐blind, 12‐week study of 193 patients with heart failure. All patients were New York Heart Association Functional Class II, III, or IV and had remained symptomatic despite optimal dosing with digoxin and diuretics. After 12 weeks of therapy, the improvement in treadmill exercise duration was greater in the lisinopril group (113 seconds) compared with the placebo group (86 seconds). This improvement in exercise duration was particularly evident in patients with left ventricular ejection fractions less than 35% (lisinopril = 130 seconds; placebo = 94 seconds). In patients receiving lisinopril, the increase in exercise duration was accompanied by an improvement in quality of life as measured by the Yale Scale Dyspnea/Fatigue Index and in signs and symptoms of heart failure. In addition, the lisinopril group had a larger mean increase (3.7%) in left ventricular ejection fraction when compared with the placebo group (1.3%). Thus, lisinopril, administered once daily for 12 weeks, was well tolerated and efficacious in the treatment of heart failure when used concomitantly with diuretics and digoxin.