Premium
Helicobacter pylori and Gastrointestinal Disease
Author(s) -
Gibaldi Milo
Publication year - 1995
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1995.tb04103.x
Subject(s) - helicobacter pylori , gastroenterology , medicine , peptic , disease , peptic ulcer , stomach , cancer , gastric acid
New paradigms are few and far between. The discovery that peptic ulcer disease is the result of an infection by a previously unrecognized microorganism rather than the consequence of excess secretion of gastric acid aptly qualifies as a paradigm shift. Eradication of Helicobacter pylori from the stomach by antibacterial agents heals ulcers at least as effectively as H 2 ‐blockers. Further, eradication of the organism results in long‐term cures of peptic ulcers. In contrast, the relapse rate in patients succesfully treated with H 2 ‐blockers exceeds 50% in the first year after healing. Also of interest is the role of H. pylori in gastric cancer .