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Lack of Effect of Tacrine Administration on the Anticoagulant Activity of Warfarin
Author(s) -
Reece Phillip A.,
Garnett William R.,
Rock William L.,
Taylor John R.,
Underwood Barbara,
Sedman Allen J.,
Rajagopalan Rukmini
Publication year - 1995
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1995.tb04099.x
Subject(s) - tacrine , warfarin , medicine , pharmacology , anticoagulant , anesthesia , atrial fibrillation , chemistry , biochemistry , acetylcholinesterase , enzyme
The effect of tacrine administration on prothrombin time was studied in 13 patients receiving prolonged warfarin therapy. After a 3‐week baseline period and 5 days of placebo administration, patients received 20 mg tacrine four times daily for 5 days. Prothrombin times were determined during baseline, daily before the morning doses of placebo and tacrine, and 14 days after the last tacrine dose (closeout). Mean (±SD) prothrombin times were 16.2 ± 2.8 seconds at baseline, 15.1 ± 2.6 seconds during the placebo phase, 15.8 ± 3.6 seconds during the tacrine phase, and 15.3 ± 3.6 seconds at closeout, indicating that tacrine has no effect on the anticoagulant activity of warfarin. Alteration of warfarin dosage should not be required in patients receiving concurrent tacrine therapy.