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Effect of Timing of Food on Absorption of Cefpodoxime Proxetil
Author(s) -
Borin Marie T.,
Driver Mary R.,
Forbes Kristi K.
Publication year - 1995
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1995.tb04095.x
Subject(s) - cefpodoxime , meal , crossover study , absorption (acoustics) , chemistry , oral administration , zoology , pharmacology , antibacterial agent , medicine , food science , biochemistry , antibiotics , biology , materials science , alternative medicine , pathology , composite material , placebo
The effect of a high‐fat meal and the timing of this meal on the absorption of a 400‐mg oral dose of cefpodoxime proxetil was evaluated in 20 healthy, adult, male volunteers in a four‐way crossover study. The area under the plasma concentration‐time curve, peak plasma concentration, and urinary recovery were significantly greater (P = .0001) after administration of cefpodoxime proxetil tablets with and 2 hours after a meal relative to dosing under fasted conditions or 1 hour before a meal. The time to peak concentration did not differ significantly among treatments, which suggests that food did not affect the rate of drug absorption. These results indicate that absorption of cefpodoxime proxetil is enhanced when tablets are taken with food or shortly after a meal.