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Comparison of the Pharmacokinetics of Two Nicotine Transdermal Systems: Nicoderm and Habitrol
Author(s) -
Gupta Suneel K.,
Okerholm Richard A.,
Eller Mark,
Wei Greg,
Rolf Clyde N.,
Gorsline Jane
Publication year - 1995
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1995.tb04093.x
Subject(s) - bioequivalence , pharmacokinetics , cotinine , nicotine , crossover study , transdermal , pharmacology , medicine , plasma concentration , washout , zoology , anesthesia , chemistry , biology , placebo , alternative medicine , pathology
This randomized, crossover study compared the nicotine and cotinine pharmacokinetic parameters and plasma concentration profiles of two different nicotine transdermal products: Nicoderm (Alza, Palo Alto, CA; and Marion Merrell Dow, Kansas City, MO) and Habitrol (Basel Pharmaceuticals, Summit, NJ). The two treatments were randomly assigned to each of 24 male smokers and worn for 24 hours each day for 5 days, with a 6‐day washout between treatments. Plasma nicotine and cotinine concentrations were measured on day 1 and day 5 of each treatment. Mean delivered dose differed significantly between products, and the two products were not bioequivalent. The Nicoderm system provided higher mean plasma nicotine concentrations, particularly during the first 8 hours after system application. The mean steady state C max , AUC, and degree of fluctuation (DF) values were significantly greater for the Nicoderm system than for Habitrol. The mean nicotine t max value for the Nicoderm system was significantly shorter ( P < .001) than that for Habitrol (2.7 versus 8.6 hours). Steady state cotinine AUC values and plasma concentrations were significantly lower for Habitrol than for the Nicoderm system. The incidence of adverse events was similar for both products .