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Drugs and Endogenous Ligands Compete for Receptor Occupancy
Author(s) -
Colburn Wayne A.
Publication year - 1994
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1994.tb04724.x
Subject(s) - endogeny , pharmacology , pharmacodynamics , pharmacokinetics , receptor , occupancy , chemistry , medicine , biology , biochemistry , ecology
Dietary and endogenous ligands compete with drugs for receptor occupancy and therefore should be considered during therapeutic interventions and during pharmacokinetic/pharmacodynamic modeling. When disease is the result of an overabundance of these natural ligands, antibodies and/or their Fab fragments may be useful as therapeutic agents to reverse the effects of the natural ligands.