Premium
Ultra‐Long‐Duration Local Anesthesia Produced by Injection of Lecithin‐Coated Tetracaine Microcrystals
Author(s) -
Boedeker Ben H.,
Lojeski Edwin W.,
Kline Mark D.,
Haynes Duncan H.
Publication year - 1994
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1994.tb02026.x
Subject(s) - tetracaine , lecithin , local anesthetic , anesthesia , chemistry , local anesthesia , local anaesthetic , medicine , chromatography , lidocaine
This study was designed to determine if microencapsulated tetracaine would provide a longer duration of local anesthesia than nonmicroencapsulated (neat) tetracaine. Local anesthesia was determined by monitoring the response of the rat to tail clamping after the installation of a subcutaneous ring block. Ten percent microencapsulated tetracaine was found to provide local anesthesia of the tail for a 43‐hour duration. Ten percent tetracaine solution was toxic. One percent tetracaine solution provided a tail block lasting 8 hours. Lecithin membranes without drug provided no block. This study demonstrates that lecithin‐coated tetracaine microcrystals produce a local anesthetic effect that is ultra‐long in duration, reversible, and not systemically toxic.