Disposition of Clozapine and Desmethylclozapine in Schizophrenic Patients | Zendy

Lin ShihKu | Zendy; Chang WenHo | Zendy; Chung MingCheng | Zendy; Lam Y. W. Francis | Zendy; Jann Michael W. | Zendy

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Disposition of Clozapine and Desmethylclozapine in Schizophrenic Patients

Author(s) -

Lin ShihKu,

Chang WenHo,

Chung MingCheng,

Lam Y. W. Francis,

Jann Michael W.

Publication year - 1994

Publication title -

the journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.92

H-Index - 116

eISSN - 1552-4604

pISSN - 0091-2700

DOI - 10.1002/j.1552-4604.1994.tb02000.x

Subject(s) - clozapine , pharmacokinetics , metabolite , disposition , pharmacology , medicine , active metabolite , schizophrenia (object oriented programming) , anesthesia , psychology , psychiatry , social psychology

The disposition of the atypical clozapine and its desmethyl metabolite were evaluated in fourteen male chronic patients. A single 100 mg dose of clozapine was administered and blood sampling performed over the following 72 hours. The mean (SD) oral clearance and half‐life of clozapine were 55.4 (29.7) L/hr and 13.7 (9.9) hours, respectively. The mean (SD) AUC for clozapine and desmethylclozapine was 2389.9 (1406) and 751.1 (622.9) ng ·; hr/mL, respectively. The elimination of the metabolite is rate limited by its formation from cloza‐pine. A wide interpatient variability in clozapine and desmethylclozapine pharmacokinetics was observed.

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