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Disposition of Clozapine and Desmethylclozapine in Schizophrenic Patients
Author(s) -
Lin ShihKu,
Chang WenHo,
Chung MingCheng,
Lam Y. W. Francis,
Jann Michael W.
Publication year - 1994
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1994.tb02000.x
Subject(s) - clozapine , pharmacokinetics , metabolite , disposition , pharmacology , medicine , active metabolite , schizophrenia (object oriented programming) , anesthesia , psychology , psychiatry , social psychology
The disposition of the atypical clozapine and its desmethyl metabolite were evaluated in fourteen male chronic patients. A single 100 mg dose of clozapine was administered and blood sampling performed over the following 72 hours. The mean (SD) oral clearance and half‐life of clozapine were 55.4 (29.7) L/hr and 13.7 (9.9) hours, respectively. The mean (SD) AUC for clozapine and desmethylclozapine was 2389.9 (1406) and 751.1 (622.9) ng ·; hr/mL, respectively. The elimination of the metabolite is rate limited by its formation from cloza‐pine. A wide interpatient variability in clozapine and desmethylclozapine pharmacokinetics was observed.