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Lack of Interaction Between Glipizide and Co‐Trimoxazole
Author(s) -
Kradjan Wayne A.,
Witt Daniel M.,
Opheim Kent E.,
Wood Francis C.
Publication year - 1994
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1994.tb01972.x
Subject(s) - glipizide , pharmacokinetics , medicine , pharmacodynamics , population , statistical significance , crossover study , half life , pharmacology , washout , gastroenterology , placebo , alternative medicine , environmental health , pathology , insulin
To identify the effects of co‐trimoxazole on the elimination and disposition kinetics of glipizide, eight healthy male volunteers were studied in an unblinded, randomized, cross‐over trial with two phases (no treatment or co‐trimoxazole 160/800 mg twice a day). During each phase, subjects were treated at home for 7 days with one of the treatment regimens, followed by a 24‐hour hospitalization for a single‐dose challenge with 10‐mg oral glipizide and detailed blood studies. A 7‐day washout period was interspersed between the phases. Pharmacokinetic and pharmacodynamic parameters were determined and compared using the Student's t‐ test for paired observations. Glipizide area under the curve (AUC), clearance, and half life for treatment and control phases were 5758 ± 1874 versus 5176 ± 1505 μg/L/hour ( P = .21), 0.41 ± 0.15 versus 0.45 ± 0.14 mL/min/kg ( P = .27), and 5.13 ± 2.10 versus 3.95 ± 1.37 hours ( P = .04), respectively. Twenty‐four‐hour glucose AUCs for treatment and control phases were 112.24 ± 8.76 versus 114.86 ± 11.98 mmol/L/hour ( P = .55), respectively. The only parameter reaching statistical significance was glipizide half life, but the difference is of doubtful clinical significance because of difficulty in identifying a clear elimination phase in several subjects. It is concluded that co‐trimoxazole administration did not significantly alter glipizide disposition and elimination kinetics in this study population .