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Combination Drug Therapy with Calcium‐Channel Blockers in the Treatment of Systemic Hypertension
Author(s) -
Frishman William H.,
Landau Andre,
Cretkovic Alexander
Publication year - 1993
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1993.tb05619.x
Subject(s) - calcium channel , medicine , drug , pharmacology , pharmacotherapy , calcium
Calcium‐channel blockers have been shown to be both safe and effective for treatment of patients with systemic hypertension. These drugs reduce peripheral vascular resistance predominantly by the inhibition of transmembrane calcium ion fluxes in vascular smooth muscle, and by this mechanism can reduce elevated blood pressure. To maximize blood pressure lowering efficacy in patients, calcium‐channel blockers have also been used in combination with other antihypertensive treatments that have included diuretics, β‐adrenergic blockers, and angiotensin‐converting enzyme inhibitors.