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The Effect of Nifedipine on the Pharmacokinetics and Dynamics of Diltiazem: The Preliminary Study in Normal Volunteers
Author(s) -
Tateishi Tomonori,
Ohashi Kyoichi,
Sudo Toshiaki,
Sakamoto Kouichi,
Fujimura Akio,
Ebihara Akio
Publication year - 1993
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1993.tb05616.x
Subject(s) - diltiazem , nifedipine , cmax , pharmacokinetics , bioavailability , pharmacology , medicine , pharmacodynamics , drug interaction , calcium
To evaluate the influence of nifedipine on the pharmacokinetics and the pharmacodynamics of diltiazem, five healthy subjects received 60 mg diltiazem orally on two occasions, diltiazem alone or after nifedipine pretreatment (10 mg three times daily for 3 days). After nifedipine pretreatment, the maximum concentration (Cmax) of diltiazem was increased and the time of Cmax was shortened, and the area under the concentration curve (AUC) tended to be increased. Although heart rate was increased, the corrected PQ interval tended to be prolonged after the nifedipine pretreatment. Both a decreased hepatic clearance and an increased bioavailability of diltiazem probably accounts for the increase in the Cmax and AUC of diltiazem after nifedipine pretreatment, and that might affect the pharmacodynamics of diltiazem.