Premium
Contrasting Effects of Pyrazinoylguanidine and Hydrochlorothiazide in Patients with Renal Insufficiency
Author(s) -
Beyer Karl H.,
Ward Thomas D.,
Vary Jean E.,
Gelarden R. Thomas,
Knutson David W.,
Vesell Elliot S.
Publication year - 1993
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1993.tb04703.x
Subject(s) - hydrochlorothiazide , medicine , endocrinology , urea , washout , cholesterol , crossover study , diuretic , chemistry , blood pressure , biochemistry , placebo , alternative medicine , pathology
A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations. The onset of PZG's antihypertensive effect occurred within 4 hours. In contrast, hydrochlorothiazide (HCTZ) increased serum concentrations of urea, triglycerides, and glucose, without affecting cholesterol.