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Impaired Elimination of Atenolol in a Nephropathie Patient with Self‐Medication Overdose
Author(s) -
ElYazigi Adnan,
Bouchama Abderrezak,
AlAbdely Hail,
Yusuf Ahmed,
Sieck Jens O.
Publication year - 1993
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1993.tb04686.x
Subject(s) - atenolol , medicine , anesthesia , emergency medicine , intensive care medicine , pharmacology , blood pressure
A case of intoxication with atenolol (plasma concentration of 2.71 mg/L) caused by an improper self‐medication combined with impaired renal function is presented. The patient was supported with atropine, isoproterenol dopamine, and dobutamine, and a thorough pharmacokinetic monitoring of atenolol was conducted. As the serum creatinine concentration returned slowly to baseline with good diuresis, the concentration of atenolol decreased (biologic half‐life = 2.95 days) and the blood pressure gradually recovered. The patient improved and was subsequently discharged in good health. Had pharmacokinetic monitoring of atenolol not been performed, hemodialysis would have been indicated.