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Effects of Oral Cimetidine or Ranitidine on the Pharmacokinetics of Intravenous Enoxacin
Author(s) -
Misiak Paul M.,
Eldon Michael A.,
Toothaker Roger D.,
Sedman Allen J.
Publication year - 1993
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1993.tb03903.x
Subject(s) - enoxacin , cimetidine , ranitidine , pharmacokinetics , pharmacology , urine , medicine , oral administration , drug interaction , antibacterial agent , chemistry , antibiotics , norfloxacin , biochemistry , ciprofloxacin
Enoxacin is a quinolone antibacterial agent currently being developed for oral and intravenous treatment of bacterial infections. Ten healthy subjects received a single 400‐mg intravenous dose of enoxacin alone, with 300 mg (four times daily) oral Cimetidine and with 150 mg (twice daily) oral ranitidine. Serial blood and urine samples were collected over a 48‐hour period. Plasma and urine enoxacin concentrations were determined using a validated high‐performance liquid chromatographic method. Mean enoxacin plasma concentrations were higher after administration of enoxacin with Cimetidine than those measured after enoxacin alone or enoxacin with ranitidine. Cimetidine coadministration reduced enoxacin renal clearance by 26% and systemic clearance by 20%, and resulted in a 30% increase in elimination half‐life. In contrast, concurrent ranitidine therapy did not significantly alter the pharmacokinetics of intravenous enoxacin.