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Treatment of Stable Chronic Bronchitis with Iodinated Glycerol: A Double‐Blind, Placebo‐Controlled Trial
Author(s) -
Repsher Lawrence H.
Publication year - 1993
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1993.tb01963.x
Subject(s) - placebo , chronic bronchitis , medicine , double blind , clinical trial , pharmacology , anesthesia , pathology , alternative medicine
In a double‐blind trial, 29 patients were treated for stable, chronic bronchitis with iodinated glycerol (Organidin®, 60 mg four times daily; n = 16) or placebo (n = 13). The study consisted of a 2‐week single‐blind lead‐in period, followed by a 6‐week double‐blind treatment period, and assessed a total of 50 response variables. In this set of patients, treatment with iodinated glycerol was associated with statistically significant (P < 0.05) and/or positive trend (P < 0.1) toward improvement in cough frequency, cough severity, difficulty in raising sputum, sputum thickness, sputum stickiness, forced expiratory flow at FVC25%–75%, cell concentration in sputum, and several measures of physician assessment of patient condition. Iodinated glycerol was well tolerated during the 6‐week treatment period; no adverse effects were reported and no patient receiving iodinated glycerol withdrew from the study prematurely. In conclusion, this study demonstrates that iodinated glycerol, 60‐mg tablets given in a total daily dose of 240 mg, is safe and effective therapy for reducing symptoms in patients with stable, chronic bronchitis.