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Effect of the Amount of Internal Standard on the Precision of an Analytical Method
Author(s) -
Jemal Mohammed,
Bergum James
Publication year - 1992
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1992.tb05781.x
Subject(s) - confidence interval , confidence region , robust confidence intervals , analyte , statistics , accuracy and precision , mathematics , chromatography , chemistry
In an earlier published paper, 2 a confidence interval approach was used to show that the use of a large amount of internal standard (relative to the analyte) would adversely affect the precision of the analytical method. However, the confidence intervals were not calculated correctly. The authors recalculated the confidence intervals and found that there is no effect on the precision as measured by the confidence intervals.