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Double‐Blind Placebo‐Controlled Trial of Terazosin Effect on Blood Pressure and Urinary Output of Dopamine in Hypertensive Patients
Author(s) -
Romero E.,
Angeli M.,
Velasco M.,
Azar E.,
Bueno O.,
Lema G.,
Morales N.,
Nuchi Y.,
Rasines C.,
Wagner A.
Publication year - 1992
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1992.tb03888.x
Subject(s) - terazosin , blood pressure , placebo , medicine , anesthesia , double blind , dopamine , urinary system , pharmacology , alternative medicine , pathology , hyperplasia
In a parallel, double‐blind study, 12 untreated hypertensive patients received terazosin (2–4 mg/day for 4 weeks), and 12 received placebo during the same period. Systolic and diastolic blood pressure decreased significantly in the terazosin group, from 150 ± 5.0 mmHg systolic and 99.6 ± 2.0 diastolic before treatment, to 134.0 ± 7.0 systolic and 85.6 ± 3.0 mmHg diastolic at week 4 of treatment. No significant blood pressure changes occurred in the placebo group. Blood pressure decrease showed a positive correlation (r = .62 and r = .52 for systolic and diastolic blood pressure, respectively) with the patient's age (P < .05). Total plasma cholesterol decreased 18% in the terazosin group (P < .05) and 9% in the placebo group (P > .05). Urinary dopamine excretion decreased significantly from 692.8 ± 180.0 to 330.5 ± 52.0 μg/24 hours in the terazosin group (P < .05) and showed a nonsignificant increase in the placebo group. Compared with 22 age‐ and sex‐matched healthy volunteers, urinary dopamine excretion in the hypertensive group before treatment was not statistically different (779.3 ± 83.1 μg/24 hours). Dopamine excretion was higher in untreated hypertensive men and in male healthy volunteers compared with women. The decrease of urinary dopamine excretion observed under terazosin treatment could be due to a decrease of kidney dopamine synthesis or release induced by blood pressure reduction, or secondarily to the blockade of kidney α 1 ‐receptors, modulating dopamine excretion. No significant changes were observed in urinary excretion of noradrenaline and adrenaline.