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Influence of Food on the Absorption of Beta‐Methyldigoxin
Author(s) -
Tsutsumi Kimiko,
Nakashima Hajime,
Kotegawa Tsutomu,
Nakano Shigeyuki
Publication year - 1992
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1992.tb03821.x
Subject(s) - beta (programming language) , absorption (acoustics) , pharmacology , medicine , chemistry , physics , computer science , optics , programming language
Nine healthy subjects received 0.2 mg of beta‐methyldigoxin (β‐MD) orally in the fasting state, 30 minutes after and before a standard breakfast. The time‐to‐peak serum glycoside concentration was delayed and the peak concentration was lower in the postprandial state compared with the other regimens (P <.01). The absorption rate constant was significantly reduced when β‐MD was given after a meal (1.55 ± 1.75 hr −1 ) than before a meal (5.54 ± 2.16 hr −1 ) and in the fasting state (5.22 ± 3.06 hr −1 )(P <.01). Although the area under the serum glycoside concentration‐time curve and the cumulative urinary excretion (CUE) of β‐MD, digoxin, and total drug (β‐MD plus digoxin) was not significantly different between three regimens, the CUE ∞ tended to be smaller in the postprandial state compared with before a meal. The results indicate that the timing of drug administration in relation to a meal is an important factor leading to the fluctuations of serum glycoside concentration after oral β‐MD, which might be of some clinical importance.