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Salivatory Responses to Classical and Nontraditional Parasympatholytic Agents in Human Subjects: Critical Comments
Author(s) -
Levin S. L.
Publication year - 1992
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1992.tb03804.x
Subject(s) - pilocarpine , pirenzepine , atropine , parasympatholytic , scopolamine , chemistry , muscarinic acetylcholine receptor , anticholinergic agents , pharmacology , psychology , neuroscience , anticholinergic , anesthesia , medicine , receptor , biochemistry , epilepsy
Both classical (atropine, scopolamine) and nontraditional (pirenzepine, telenzepine) cholinolytic agents themselves cause no salivation in human subjects. Ordinarily, they block salivation caused by pilocarpine. Conversely, they all stimulate intense salivatory response in the chronically denervated human parotid gland. The author presents critical comments on the concept that cholinolytic agents cause salivation by suppression of the mechanism of presynaptic autoinhibition. An alternative explanation of the initial cholinomimetic effect of cholinolytic agents is suggested.