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Effect of Cimetidine Administration on the Pharmacokinetics of Pirmenol
Author(s) -
Stringer Kathleen A.,
Lebsack M. E.,
CetnarowskiCropp Anne B.,
Goidfarb Alien L.,
Raduiovic Louis L.,
Bockbrader Howard N.,
Chang Tsun,
Sedman Allen J.
Publication year - 1992
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1992.tb03794.x
Subject(s) - cimetidine , pharmacokinetics , medicine , pharmacology , oral administration
The potential for a drug—drug interaction between pirmenol, an extensively metabolized antiarrhythmic agent, and cimetidine, an inhibitor of hepatic drug‐metabolizing enzymes, was evaluated in eight healthy adults. A single 150‐mg oral dose of pirmenol was administered on study days 1 and 8 and oral cimetidine, 300‐mg qid , was administered on study days 4 through 11. Plasma and urine samples were collected after each pirmenol dose for determination of pirmenol concentration. Mean pirmenol concentration—time curves and pharmacokinetic parameters, including elimination rate constant, were not significantly altered by concomitant administration of cimetidine.