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Drug‐Food Interaction Potential of Clarithromycin, A New Macrolide Antimicrobial
Author(s) -
Chu Souyie,
Park Y.,
Locke Charles,
Wilson David S.,
Cavanaugh J. C.
Publication year - 1992
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1992.tb03784.x
Subject(s) - clarithromycin , bioavailability , metabolite , pharmacokinetics , ingestion , pharmacology , absorption (acoustics) , drug , dosing , active metabolite , medicine , antibacterial agent , oral administration , drug interaction , plasma concentration , antibiotics , chemistry , helicobacter pylori , biochemistry , physics , acoustics
To evaluate the effect of food on bioavailability, clarithromycin and 14‐hydroxy clarithromycin (active metabolite) pharmacokinetics were assessed in 26 healthy adult volunteers after ingestion of a single oral 500‐mg dose of clarithromycin in a fasting state (2 hours before breakfast after an overnight fast) and a nonfasting state (0.5 hours after the start of breakfast). Clarithromycin and 14‐hydroxy metabolite plasma concentrations were measured using a high‐performance liquid chromatographic technique. Food intake immediately before dosing increased the extent of absorption from the 500‐mg tablet formulation by approximately 25%. The mean increase in metabolite area under the plasma concentration‐time curve was approximately 9%. These results suggest that clarithromycin can be taken without regard to timing in relation to meals.