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Lack of Effect of a High‐Fat Meal on the Volume of Distribution of Theophylline in Humans
Author(s) -
Parish Roy C.,
Wade William E.,
Middendorf Wayne F.
Publication year - 1991
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1991.tb04970.x
Subject(s) - theophylline , volume of distribution , aminophylline , pharmacokinetics , elimination rate constant , meal , medicine , dosing , population , distribution (mathematics) , chemistry , endocrinology , mathematical analysis , mathematics , environmental health
The pharmacokinetics of intravenously administered theophylline were studied in five healthy nonsmokers. Each subject received 5 mg/kg of theophylline as aminophylline after an overnight fast and again after a standard high‐fat meal. Although there was wide between‐day variation in the elimination rate constant in three of the five subjects, no statistically significant differences were observed in area under the time‐versus‐concentration curve, maximum serum theophylline concentration, elimination rate constant, or apparent volume of distribution between the two treatments. A statistical power analysis indicated that if differences in volume of distribution and maximum serum theophylline concentration occur in the general population, the mean differences are less than 15% and 20%, respectively. This suggests that alterations in intravascular drug distribution resulting from eating a high‐fat meal do not contribute importantly to previously reported effects of food on serum theophylline concentrations after oral dosing.