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Theophylline Pharmacokinetics: Effect of Continuous Versus Intermittent Cimetidine IV Infusion
Author(s) -
Gaska Janice A.,
Tietze Karen J.,
Rocci Mario L.,
Vlasses Peter H.
Publication year - 1991
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1991.tb03754.x
Subject(s) - cimetidine , theophylline , aminophylline , pharmacokinetics , volume of distribution , medicine , anesthesia , pharmacology
The comparative effects of continuous versus intermittent cimetidine infusion on theophylline pharmacokinetics were evaluated in 12 nonsmoking healthy male volunteers. Each subject received aminophylline 0.9 mg/kg/hr over 6 hours alone (control) and in random order at 1 week intervals, in combination with intermittent cimetidine (300 mg IV over 15 minutes every 6 hours) and continuous cimetidine (50 mg/hr W) infusions. Both cimetidine regimens were administered for a total of 50 hours. Serial plasma samples were obtained and assayed for theophylline by HPLC. No significant differences existed in mean theophylline clearance and mean volume of distribution among control, intermittent or continuous cimetidine regimens; the power was >80% to detect a 30% change in clearance. Only a minor difference in theophylline half‐life between control and continuous cimetidine infusion (7.59 ± 2.52 vs. 9.05 ± 3.17 hr ; P < .05) was observed. These findings do not support a clinically significant interaction between IV aminophylline and cimetidine administered IV either as a low dose continuous infusion or as an intermittent infusion .