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New Pharmacokinetic Methods III. Two Simple Tests for “Deep Pool Effect”
Author(s) -
Browne Thomas R.,
Greenblatt David J.,
Schumacher Gerald E.,
Szabo George K.,
Evans James E.,
Evans Barbara A.
Publication year - 1990
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1990.tb03626.x
Subject(s) - pharmacokinetics , pharmacology , compartment (ship) , drug , chemistry , medicine , geology , oceanography
If a portion of administered drug is distributed into a “deep” peripheral compartment, the drug's actual elimination half‐life during the terminal exponential phase of elimination may be longer than determined by a single dose study or a tracer dose study (“deep pool effect”). Two simple methods of testing for “deep pool effect” applicable to drugs with either linear or nonlinear pharmacokinetic properties are described. The methods are illustrated with stable isotope labeled ( 13 C 15 N 2 ) tracer dose studies of phenytoin. No significant ( P < .05) “deep pool” effect was detected.