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Estimation of Hepatic Blood Flow in Branches of Hepatic Vessels Utilizing a Noninvasive, Duplex Doppler Method
Author(s) -
Horn John R.,
Zierler Brenda,
Bauer Larry A.,
Reiss William,
Strandness D. E.
Publication year - 1990
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1990.tb03572.x
Subject(s) - blood flow , indocyanine green , medicine , ultrasound , hemodynamics , doppler effect , imaging phantom , artery , biomedical engineering , vein , doppler ultrasound , radiology , nuclear medicine , cardiology , pathology , physics , astronomy
The measurement of hepatic blood flow by indirect methods such as indocyanine green clearance has several limitations. The duplex Doppler offers the potential for noninvasive, real‐time measurement of blood flow and has been employed in the evaluation of arterial disease in a variety of vascular beds. We evaluated Doppler ultrasound estimation of blood flow in branches of the hepatic artery, hepatic vein, and portal vein in 12 healthy subjects on two separate days. In vitro accuracy of the scanner was assessed using phantom targets of known diameter and velocity. Blood velocity and vessel diameter measurements were obtained five times over a period of 2 hours. No significant differences were seen in velocity or blood flow measurements within or between days. The interday coefficients of variation, which include intrasubject variability, were 10–15% and 14–20% for velocity and blood flow measurements, respectively. This study demonstrates the potential utility of Doppler ultrasound to detect intrinsic, drug, or disease‐induced changes in hepatic blood flow.