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Effect of Short‐Term Beta Blockade on Serum Lipid Levels and on the Interaction of LDL with Human Arterial Proteoglycans
Author(s) -
Lindén Tomas,
Camejo Germán,
Wiklund Olov,
Warnold Ingrid,
Olofsson SvenOlof,
Bondjers Göran
Publication year - 1990
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1990.tb03510.x
Subject(s) - metoprolol , atenolol , lipoprotein , medicine , beta (programming language) , endocrinology , blockade , low density lipoprotein , cholesterol , myocardial infarction , chemistry , pharmacology , receptor , blood pressure , computer science , programming language
In view of conflicting evidence suggesting that beta‐blockers have an anti‐atherogenic effect as well as induce a potentially atherogenic lipoprotein profile, the effects of a short term beta‐blockade on serum lipoproteins were studied in 39 healthy volunteers. Because the interaction of LDL with arterial proteoglycans appears to play a role in lipoprotein accumulation during atherogenesis, the effects of metoprolol and atenolol on low density lipoprotein interaction with human aortic proteoglycans were included in the study. We could confirm that the beta‐blockers caused a decrease in HDL cholesterol and an increase in triglycerides, both potentially undesirable effects. In addition, however they induced a significant decrease in the in vitro LDL affinity for arterial proteoglycans. Since there appears to be a strong association between LDL reactivity with proteoglycans and risk for myocardial infarction, this effect of the beta‐blockers may be an antiatherogenic effect which overrides other effects on the lipoprotein pattern.