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ACE Inhibition and Pressor Responsiveness to Norepinephrine in Hypertensive Patients
Author(s) -
Malini Pier L.,
Strocchi Enrico,
Valtancoli Giampaolo,
Ambrosioni Ettore
Publication year - 1990
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1990.tb03480.x
Subject(s) - lisinopril , captopril , hydrochlorothiazide , medicine , diuretic , norepinephrine , ace inhibitor , blood pressure , angiotensin converting enzyme , renin–angiotensin system , pressor response , endocrinology , vasoconstriction , pharmacology , heart rate , dopamine
The pressor response to norepinephrine (NE) was assessed in normal renin essential hypertensive patients before and after they were randomly assigned to receive in parallel groups of treatment a single dose of an angiotensin converting enzyme (ACE) inhibitor (captopril or lisinopril) or a prolonged therapy with lisinopril (30–45 days) or with hydrochlorothiazide (9 days). Blood pressure was significantly reduced by all treatments. The pressor response to NE was unchanged after the single administration of the ACE inhibitors, while it was blunted after chronic administration of lisinopril and after the diuretic. On the basis of these results, it is suggested that the attenuation of the sympathetically mediated vasoconstriction may represent an additional mechanism contributing to the antihypertensive effect of ACE inhibitors administered chronically.