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Penbutolol and Carteolol: Two New Beta‐Adrenergic Blockers with Partial Agonism
Author(s) -
Frishman William H.,
Covey Steven
Publication year - 1990
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1990.tb03479.x
Subject(s) - pindolol , propranolol , partial agonist , agonism , bradycardia , beta (programming language) , pharmacology , agonist , adrenergic agonist , medicine , adrenergic beta antagonists , adrenergic , chemistry , heart rate , blood pressure , receptor , politics , political science , computer science , law , programming language
Penbutolol and carteolol are two new long acting, nonselective beta‐adrenergic blockers which have been approved for the treatment of systemic hypertension. Both drugs have intrinsic sympathomimetic activity (partial agonist activity), however, less than that seen with pindolol. They appear to cause less resting bradycardia than propranolol, have no effect on lipids and lipoproteins, and have favorable side effect profiles.