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Steady State Pharmacokinetics of Propranolol in Saudi Arabian Patients and Comparison with Data for Different Populations
Author(s) -
ElYazigi Adnan,
ElBaage Thar,
AlHumaidan Abdulkarim,
Yusuf Ahmed
Publication year - 1990
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1990.tb03453.x
Subject(s) - propranolol , pharmacokinetics , medicine , dosing , body weight , steady state (chemistry) , oral administration , zoology , gastroenterology , chemistry , biology
The steady state pharmacokinetics of propranolol was examined in 48 Saudi Arabian patients chronically treated with oral doses [mean (SEM) = 85.8 (5) mg] of this drug. The mean (SEM) of the steady state concentration (C ss ) per mg/kg daily dose was 21.8 (3.1) ng · ml −1 /mg · kg −1 . A 6‐fold variability in C ss was observed between patients treated with 40 mg every 8 hours and 14‐fold between patients treated with 40 mg twice daily. The frequency distribution of the apparent oral clearance (TCL or ) of propranolol was bimodal with 88% of the patients showing TCL or of 18 to 372 l · hr −1 while the remainder had TCL or of 471 to 749 l · hr −1 . The mean (SEM) of the TCL or per kg body weight for all 48 patients was 3.16 (0.38) l · hr −1 · kg −1 . Both C ss and TCL or obtained for Saudi Arabian patients are not significantly different from those reported for subjects from Western populations. While C ss increased proportionally ( P < .001) with dosing, a near‐significant ( P < .06), inverse, linear relationship was found between age and TCL or . No significant effect of sex, body weight, or disease state (i.e., heart diseases, hypertension, depression, migraine) on C ss or TCL or was detected .