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The Influence of Fever on the Pharmacokinetics of Pranoprofen in Elderly Subjects
Author(s) -
Fujimura Akio,
Kajiyama Hiroyuki,
Ebihara Akio
Publication year - 1989
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1989.tb03371.x
Subject(s) - volume of distribution , pharmacokinetics , dose , medicine , plasma clearance , plasma concentration , distribution (mathematics) , half life , anesthesia , gastroenterology , mathematics , mathematical analysis
Pranoprofen (75 mg) was given orally during febrile (mean body temperature 38.3°C) and afebrile (mean body temperature 36.3°C) periods in nine elderly subjects. Blood samples for plasma drug concentrations were taken for a 10 hour post‐drug period. The mean elimination half‐life (t 1/2β ) was significantly prolonged and the mean area under the time‐concentration curve from 0 to 10 hrs (AUC 0–10 ) was greater, although not significantly, during fever. No significant difference was observed in the time to maximum concentration (t max ), maximum plasma concentration (C max ) or apparent volume of distribution (Vd/F) between the both dosages. There was a positive correlation (r = 0.448, 0.05 < P < 0.10) between the body temperature and t 1/2β of pranoprofen . These data indicate that the clearance of pranoprofen is reduced during fever in elderly subjects.