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Pharmacokinetics of Capacity‐Limited Systems
Author(s) -
Jusko William J.
Publication year - 1989
Publication title -
the journal of clinical pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1989.tb03369.x
Subject(s) - pharmacy , library science , citation , state (computer science) , computer science , medicine , family medicine , algorithm
Nonlinearities are commonplace in pharmacokinetics and most frequently occur because of a limited concentration of biological material available for interaction with relatively high concentrations of drugs. The Michaelis-Menten-type function can be applied to metabolism, transport, and binding phenomena that display capacity-limitation. Nonlinear systems can be handled with differential equations (directly or converted to linear form), integrated equations (in non-closed form) or with relatively new area/moment or MRT relationships. Drug disposition studies should include several dose levels and recommendations are provided for detecting the presence of one or more nonlinear absorption or disposition processes in typical experimental data.