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Effects of Traxanox Sodium on Blood Pressure and Serum Uric Acid in Hypertensive Patients: A Preliminary Study
Author(s) -
Fujimura Akio,
Ebihara Akio,
Hino Naoko,
Koike Yuichi
Publication year - 1989
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1989.tb03336.x
Subject(s) - uric acid , blood pressure , medicine , placebo , urinary system , excretion , endocrinology , sodium , chemistry , pathology , alternative medicine , organic chemistry
The effects of chronic administration of traxanox sodium (traxanox) on blood pressure and serum uric acid level were investigated in 15 patients who had mild to moderate hypertension. Traxanox or its placebo was orally administered in a single‐blind protocol. Blood pressure was significantly reduced from baseline after treatment with traxanox. The serum uric acid level after drug administration was significantly lower than with placebo whereas urinary uric acid excretion was significantly greater and uric acid clearance tended to be greater. These results indicate that chronic administration of traxanox reduces serum uric acid level as well as blood pressure in patients with mild to moderate hypertension. This reduction in serum uric acid is due in part to a traxanox‐induced elevation of urinary uric acid excretion.