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Dosing Regimen of Gentamicin During Intermittent Peritoneal Dialysis
Author(s) -
Kaojarern Sming,
Arkaravichien Wiwat,
Indraprasit Suchati,
Pummangura Chalermsri
Publication year - 1989
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1989.tb03302.x
Subject(s) - dosing , medicine , peritoneal dialysis , gentamicin , regimen , antibiotics , intensive care medicine , urology , chemistry , biochemistry
The peritoneal clearance of gentamicin was studied in 11 chronic uremic patients who undergoing intermittent peritoneal dialysis. Gentamicin was significantly removed by peritoneal dialysis with a clearance value of 9.75 ± 3.78 ml/min. The serum half life was 14.08 ± 3.57 hr, a value significantly less than that of non dialysed end stage renal disease patients. The mean apparent volume of distribution of the drug in these patient was about 27% of body weight. The derived value for gentamicin peritoneal clearance and volume of distribution can be used to calculate maintenance dose during intermittent peritoneal dialysis. In order to achieve the peak level of 8 ug/ml, supplementary dose compensated for the loss during peritoneal dialysis is approximately 40% of loading dose 0.8 mg/kg every 12 hours.