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Nizatidine Suppression of Basal Gastric Acid Output: A Comparison of Two Intravenous Dosage Regimens
Author(s) -
Danziger Larry,
Furmaga Kevin M.,
Rodvold Keith A.,
Bombeck C. Thomas,
Fischer James H.
Publication year - 1989
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1989.tb03259.x
Subject(s) - medicine , basal (medicine) , pharmacology , gastric acid , intravenous infusions , anesthesia , stomach , insulin
To study the pharmacokinetics and pharmacodynamics of two intravenous nizatidine dosing regimens, serial plasma concentrations and continuous intragastric pH were monitored simultaneously in 10 subjects with a documented history of duodenal or gastric ulcers. A 24‐hour gastric pH profile was characterized for a 300 mg daily dose of nizatidine randomly administered both as 100 mg every 8 hours and 150 mg every 12 hours. No significant differences were observed in the mean pharmacokinetic parameters between the two dosing regimens. Pharmacodynamic parameters for the 100 mg every 8 hours versus the 150 mg every 12 hours regimen were not significantly different except for percent of time during the 24‐hour study period that the pH was maintained >4 (43.6 ± 20.7 versus 34.7 ± 18.3, P < .05). A significant relationship was demonstrated for both regimens (P < .05) between the percent time pH > 4 and area under the plasma curve for the 24 hour study period. The lack of a significant difference in nizatidine pharmacokinetics between the two dosage regimens suggests a pharmacodynamic cause for the greater cumulative pH effect of the every 8 hour regimen.