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Pharmacokinetics of Diltiazem in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
Author(s) -
GrechBélanger Odette,
Langlois Serge,
LeBoeuf Elizabeth
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb05763.x
Subject(s) - diltiazem , continuous ambulatory peritoneal dialysis , pharmacokinetics , medicine , diltiazem hydrochloride , ambulatory , dialysis , metabolite , peritoneal dialysis , active metabolite , oral administration , elimination rate constant , urology , anesthesia , pharmacology , calcium , volume of distribution
The disposition of a single oral dose of diltiazem hydrochloride was studied in six male patients treated by continuous ambulatory peritoneal dialysis. Peak concentrations were obtained 2 to 4 hours postdose. The mean absorption rate constant was 0.94 ± 0.21 (sd) hr ‐1 , and the mean elimination half‐life was 3.09 ± 1.16 hr. Serum levels of deacetyldiltiazem, a metabolite of diltiazem, were always below 10 ng/mL. The amounts of diltiazem and deacetyldiltiazem eliminated in dial ysate over 24 hours represent less than 0.1% of the administered dose. The pharmacokinetic parameters of diltiazem determined in these patients did not differ from those determined in healthy volunteers and in patients suffering from end‐stage renal disease.