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Superactivated Charcoal Versus Cholestyramine for Cholesterol Lowering: A Randomized Cross‐Over Trial
Author(s) -
Park Glen D.,
Spector Reynold,
Kitt Therese M.
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb05752.x
Subject(s) - cholestyramine , charcoal , cholesterol , regimen , medicine , crossover study , cholesterol lowering , randomized controlled trial , activated charcoal , chemistry , gastroenterology , endocrinology , zoology , biology , alternative medicine , organic chemistry , adsorption , pathology , placebo
To evaluate the relative abilities of superactivated charcoal (20 g twice daily) and cholestyramine (8 g twice daily) to lower plasma cholesterol concentrations acutely, six hyper‐cholesterolemic patients were studied using a randomized cross‐over design. After a 1‐week dietary control period, each subject received 3 weeks of each treatment regimen on separate occasions. Superactivated charcoal and cholestyramine reduced total plasma cholesterol by 21.8 ± 3.8% and 16.2 ± 2.4%, respectively. Side effects were mild and similar for both treatments. At the dosage regimens studied, superactivated charcoal and cholestyramine have comparable ability to lower plasma cholesterol concentrations.