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Comparative Bioavailability of Suprofen After Coadministration with Food or Milk
Author(s) -
Chaikin Philip,
Marriott Thomas B.,
Simon David,
Weintraub Howard S.
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb05730.x
Subject(s) - bioavailability , medicine , meal , confidence interval , pharmacokinetics , analgesic , geometric mean , nonsteroidal , pharmacology , statistics , mathematics
Suprofen is a nonsteroidal analgesic with demonstrated efficacy in the treatment of mild to moderate pain associated with a variety of clinical conditions. Because nonsteroidal analgesic agents may cause gastrointestinal side effects, they are frequently prescribed with food or milk. The purpose of this study was to evaluate the effects of a standard meal and milk alone on the rate and extent of absorption of suprofen. In a randomized three‐way cross‐over study, 24 healthy volunteers each received a single 200‐mg oral dose of suprofen in the fasted state half an hour after a standard meal or half an hour after an 8‐ounce glass of milk. The influence of food and milk was greater on the rate than on the extent of absorption of suprofen as illustrated by a more pronounced effect on C max than on AUC. In addition, food had a greater influence on the bioavailability of suprofen than milk. Food decreased the mean C max to 44% and the mean AUC to 81% relative to the fasted state, whereas milk decreased the mean C max to 74% and the mean AUC to only 87% of the respective parameters in the fasted state. Symmetrical confidence intervals demonstrated that the mean AUC milk was within only 19% and the mean AUC food was within only 25% of the mean AUC in the fasted state, with 95% confidence.